# DBT JRF 2020 — Question 20

Exam: DBT JRF 2020 · Section: B · Topic: Genetics · Difficulty: Easy

## Question

One centimorgan is defined as the genetic distance between two loci with a statistically corrected recombination frequency of

## Options

- **A.** 10%
- **B.** 0.5%
- **C.** 0.1%
- **D.** 1%

## Answer

Option D

## Explanation

Lectins are carbohydrate-binding proteins/glycoproteins of non-immune origin that bind specifically and non-covalently to particular mono- or oligosaccharide structures. They are used as probes in glycobiology: Concanavalin A (Con A) → α-D-mannose, α-D-glucose; Wheat Germ Agglutinin (WGA) → GlcNAc, sialic acid; Peanut Agglutinin (PNA) → β-Gal-(1→3)-GalNAc. Lectin blotting (similar to Western blotting) resolves glycoproteins by SDS-PAGE, transfers to membrane, and detects with labelled lectins — revealing the glycan composition and pattern (glycoform). Lectins can also be used in affinity chromatography to purify glycoproteins.

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