# DBT JRF 2020 — Question 38

Exam: DBT JRF 2020 · Section: B · Topic: Biochemistry · Difficulty: Easy

## Question

Cellulose is a linear polymer of glucose with

## Options

- **A.** bet1,3-glycosidic linkage
- **B.** alph1,4-glycosidic linkage
- **C.** alph1,3-glycosidic linkage
- **D.** bet1,4-glycosidic linkage

## Answer

Option D

## Explanation

Trabectedin (ecteinascidin-743, ET-743; brand name Yondelis) was originally isolated from the Caribbean tunicate (sea squirt) Ecteinascidia turbinata. It is a tetrahydroisoquinoline alkaloid that acts as a DNA minor groove alkylator, forming covalent adducts with guanine N2 and bending DNA toward the major groove, thereby interfering with transcription-coupled nucleotide excision repair and disrupting gene transcription in tumour cells. It is approved for soft tissue sarcoma and ovarian cancer (EU and USA). Avastin = bevacizumab (anti-VEGF monoclonal antibody); Abraxane = nab-paclitaxel; Adriamycin = doxorubicin (anthracycline from Streptomyces).

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