# DBT JRF 2020 — Question 120

Exam: DBT JRF 2020 · Section: B · Topic: Biotechnology · Difficulty: Medium

## Question

Which of these procedures poses the least risk to an unborn child?

## Options

- **A.** amniocentesis
- **B.** embryoscopy & fetoscopy
- **C.** alphfeto protein sampling
- **D.** chorionic villi sampling

## Answer

Option C

## Explanation

Prenatal diagnostic procedures and relative fetal risk: Amniocentesis (performed at 15–20 weeks gestation) — needle aspiration of amniotic fluid; miscarriage risk ~0.1–0.5%. Chorionic Villi Sampling/CVS (at 10–13 weeks) — biopsy of placental chorionic villi; miscarriage risk ~0.5–1%. Embryoscopy/Fetoscopy — direct endoscopic visualisation of the fetus; highest invasive risk ( $>$ 1–2% miscarriage). Alpha-fetoprotein (AFP) sampling — a maternal SERUM (blood) test, non-invasive, no procedure-related fetal risk. AFP is elevated in neural tube defects (NTD: anencephaly, spina bifida) and abdominal wall defects, and low in Down syndrome (Trisomy 21). As a blood test from the mother, AFP poses LEAST risk to the unborn child.

Source: https://mypyqbuddy.com/questions/which-of-these-procedures-poses-the-least-risk-6a05a8a02adafec470293290