# DBT JRF 2022 — Question 3

Exam: DBT JRF 2022 · Section: A · Topic: Molecular Biology › Eukaryotic Promoters & Transcription Initiation · Difficulty: Medium

## Question

The motifs commonly found in the core promoter of eukaryotic protein coding genes are:

## Options

- **A.** TATA and Pribnow box
- **B.** Motif ten element and TATA
- **C.** BRE and Kozak consensus sequence
- **D.** TRE and TATA

## Answer

Option B

## Explanation

Core promoter elements in eukaryotic protein-coding genes: • TATA box: Located ~25–30 bp upstream of the transcription start site (TSS); recognised by TATA-Binding Protein (TBP), a subunit of TFIID. • Motif Ten Element (MTE): Located ~18–27 bp downstream of the TSS; functions similarly to the TATA box in directing Pol II. Distractors explained: • Pribnow box (TATAAT): Found in prokaryotic promoters at −10; NOT in eukaryotes. • Kozak consensus sequence: Surrounds the AUG start codon in eukaryotic mRNAs; it is a translation initiation signal, not a transcription promoter element. • BRE (TFIIB Recognition Element): Located upstream of the TATA box; recognised by TFIIB, not TFIID. • TRE (TPA Response Element): A transcriptional enhancer element responsive to phorbol esters, not a core promoter motif.

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