# DBT JRF 2022 — Question 27

Exam: DBT JRF 2022 · Section: B · Topic: Microbiology › Human Microbiome & Dysbiosis · Difficulty: Medium

## Question

The term Dysbiosis is associated with:

## Options

- **A.** Kinome
- **B.** Immunome
- **C.** Genome
- **D.** Microbiome

## Answer

Option D

## Explanation

Dysbiosis and the microbiome: Dysbiosis refers to a disruption or imbalance in the composition, diversity, and function of the microbiome (the community of microorganisms inhabiting the human body, especially the gut). Key features of dysbiosis: • Reduced microbial diversity • Overgrowth of potentially pathogenic taxa (e.g., Clostridioides difficile) • Loss of beneficial commensals (e.g., Faecalibacterium prausnitzii) Associated conditions: • Inflammatory bowel disease (IBD): Crohn's disease, ulcerative colitis • Obesity and metabolic syndrome • Type 2 diabetes • Colorectal cancer • Depression and neurological disorders (gut-brain axis) The term is specifically associated with the MICROBIOME (not genome, immunome, or kinome). Answer: Microbiome (Option 4).

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