# DBT JRF 2022 — Question 30

Exam: DBT JRF 2022 · Section: B · Topic: Molecular Biology › Promoter Elements & Transcription · Difficulty: Medium

## Question

TATA box involved in the initiation of transcription is located in the:

## Options

- **A.** Promoter region
- **B.** Enhancer region
- **C.** Exon region
- **D.** Intron region

## Answer

Option A

## Explanation

TATA box: location and function: The TATA box (consensus: TATAAA) is a core promoter element: • Location: ~25-30 bp UPSTREAM of the transcription start site (TSS), in the PROMOTER region. • Function: Recognised by TBP (TATA-Binding Protein), the universal component of TFIID, which nucleates pre-initiation complex assembly. • TATA-box containing genes: often highly regulated, tissue-specific, or stress-responsive. • ~30% of eukaryotic promoters have a TATA box; the rest use other core elements (Inr, DPE, MTE, BRE). Distractors: • Enhancer: a cis-regulatory element that can be far from the promoter and in any orientation; it increases transcription but is NOT where TATA box is found. • Exon: part of the mRNA coding/flanking sequence. • Intron: non-coding intervening sequence; not part of the promoter. Answer: Promoter region (Option 1).

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