# DBT JRF 2022 — Question 88

Exam: DBT JRF 2022 · Section: B · Topic: Plant Biology › Transcription Factors - NAC Family · Difficulty: Medium

## Question

The most likely sub-cellular localization of NAC transcription factors is:

## Options

- **A.** Nucleus
- **B.** Cytoplasm
- **C.** Mitochondria
- **D.** Plastid

## Answer

Option A

## Explanation

NAC transcription factors in plants: NAC is one of the largest plant-specific transcription factor families (NAM-ATAF-CUC): • Name origin: No Apical Meristem (NAM), Arabidopsis Transcription Activator Factor 1/2 (ATAF1/2), Cup-Shaped Cotyledon 2 (CUC2) • ~117 members in Arabidopsis, >150 in rice. Structure: N-terminal NAC domain (DNA-binding + dimerisation) + C-terminal transcriptional activation/repression domain. Subcellular location: NUCLEUS (they are transcription factors that bind DNA and regulate gene expression). Functions: • Stress responses: drought (ANAC019, ANAC055), heat, cold stress • Leaf senescence: NAC transcription factors orchestrate senescence programme • Development: shoot apical meristem formation (CUC1, CUC2), wood formation • Pathogen responses Answer: NAC transcription factors are plant-specific, localise to the nucleus, and regulate stress, senescence, and developmental gene expression.

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