# DBT JRF 2022 — Question 118

Exam: DBT JRF 2022 · Section: B · Topic: Bioinformatics › RNA Secondary Structure Prediction · Difficulty: Medium

## Question

Given below are two statements: Statement I: RNA secondary structure is composed primarily of double-stranded RNA regions formed by folding of the single-stranded molecule back on itself. Statement II: Like protein secondary structure, RNA secondary structure can be conveniently viewed as an intermediate step in the formation of a three-dimensional structure. In the light of the above statements, choose the most appropriate answer from the options given below:

## Options

- **A.** Both Statement I and Statement II are correct
- **B.** Both Statement I and Statement II are incorrect
- **C.** Statement I is correct but Statement II is incorrect
- **D.** Statement I is incorrect but Statement II is correct

## Answer

Option A

## Explanation

RNA secondary structure: analogy to protein secondary structure: RNA is a single-stranded molecule that folds upon itself through intramolecular base pairing (A-U, G-C, and non-canonical G-U wobble pairs) to form secondary structures: • RNA secondary structures: stem-loops/hairpins, internal loops, bulges, multi-branch loops, pseudoknots. • These are double-stranded regions formed by base-pairing within the single-stranded RNA molecule. Analogy to protein structure: • Primary structure: sequence (nucleotides for RNA; amino acids for proteins) • Secondary structure: local regular structures (stem-loops for RNA; $\alpha$ -helices and $\beta$ -sheets for proteins) • Tertiary structure: overall 3D fold (for rRNA, tRNA, ribozymes; protein domain folds) RNA secondary structure is the intermediate structural organisation — double-stranded regions within a single-stranded molecule — analogous to local folding in proteins. Answer: RNA secondary structure (stems and loops from intramolecular base pairing) is analogous to protein secondary structure.

Source: https://mypyqbuddy.com/questions/given-below-are-two-statements-statement-i-rna-6a104cd5920734408bc0c785