Which of the following organelle is NOT a site for Reactive Oxygen Species (ROS) generation?
Which of the following organelle is NOT a site for Reactive Oxygen Species (ROS) generation?
Select an option to attempt
Correct Answer: Option B
Explanation
Reactive Oxygen Species (ROS) generation sites in eukaryotic cells: Mitochondria — the major source: electron leakage at Complex I (NADH dehydrogenase) and Complex III (ubiquinol-cytochrome c reductase) transfers single electrons to, forming superoxide (). Peroxisomes —-oxidation of very long chain fatty acids and amino acid catabolism produces; catalase converts it to. Endoplasmic Reticulum — protein disulfide bond formation during oxidative folding by Ero1 (ER oxidoreductin 1) and PDI generates. NADPH oxidase (NOX) at plasma membrane — in phagocytes, produces superoxide for pathogen killing. The NUCLEUS contains antioxidant enzymes (thioredoxin, PRDX) and DNA repair mechanisms but is NOT a significant ROS-generating site.