Which one of the following is the drug of choice for sexually transmitted diseases urethritis and cervicitis caused by Chlamydia trachomatis?
Which one of the following is the drug of choice for sexually transmitted diseases urethritis and cervicitis caused by Chlamydia trachomatis?
Select an option to attempt
Correct Answer: Option D
Explanation
First-line treatment for Chlamydia trachomatis:Chlamydia trachomatis is an obligate intracellular bacterium. Being intracellular, treatment must use antibiotics that penetrate cells.First-line treatments (CDC guidelines):• Azithromycin (single 1g oral dose): macrolide antibiotic; concentrates intracellularly; excellent for single-dose compliance.• Doxycycline (100 mg BID for 7 days): tetracycline; penetrates intracellularly; effective and inexpensive.Chlamydia has no peptidoglycan cell wall → beta-lactam antibiotics (ampicillin, penicillin) are INEFFECTIVE (no target for their mechanism of action).Other antibiotics: Levofloxacin and erythromycin are alternatives but not first-line.Answer: Azithromycin (single dose) or Doxycycline (7 days).