Which one of the following statements is most relevant to leishmaniasis?

Select an option to attempt

1. A
   Large domestic animals such as cattle are the principal reservoir of L. donovani
2. B
   Both visceral leishmaniasis and cutaneous leishmaniasis are transmitted by the bite of sandflies.
3. C
   Artemisinin is effective in the treatment of leishmaniasis.
4. D
   Leishmaniasis is transmitted by the bite of female Anopheles mosquitoes.