Amide bonds between two amino acids (as shown below) are generally in trans-conformation. The atoms are labeled as A1 through A6. The angle measured…
Amide bonds between two amino acids (as shown below) are generally in trans-conformation. The atoms are labeled as A1 through A6. The angle measured for defining the trans-conformation of the amide bond is the angle between:
Select an option to attempt
Correct Answer: Option D
Explanation
Omega dihedral angle and trans-conformation of the peptide bond:The peptide bond's conformation is described by the omega (ω) dihedral angle, measured around the C-N bond.Dihedral angle measurement:• Theωangle is defined by 4 consecutive atoms:Cα1−C−N−Cα2• This corresponds to atoms A2-A3-A4-A6 in the labelling of the question.• In practice, it is measured as the angle between the two PLANES: plane(A2,A3,A4) and plane(A3,A4,A6).In the trans-conformation:ω=180°(the two Cα atoms are on opposite sides of the peptide bond). ~99.9% of peptide bonds are trans.In the cis-conformation:ω=0°(less stable, mostly found before Pro residues — ~5%).Answer: Planes formed by A2,A3,A4 and A3,A4,A6 (Option 4).