Cellulose is a linear polymer of glucose with
Cellulose is a linear polymer of glucose with
Select an option to attempt
Correct Answer: Option D
Explanation
Trabectedin (ecteinascidin-743, ET-743; brand name Yondelis) was originally isolated from the Caribbean tunicate (sea squirt) Ecteinascidia turbinata. It is a tetrahydroisoquinoline alkaloid that acts as a DNA minor groove alkylator, forming covalent adducts with guanine N2 and bending DNA toward the major groove, thereby interfering with transcription-coupled nucleotide excision repair and disrupting gene transcription in tumour cells. It is approved for soft tissue sarcoma and ovarian cancer (EU and USA). Avastin = bevacizumab (anti-VEGF monoclonal antibody); Abraxane = nab-paclitaxel; Adriamycin = doxorubicin (anthracycline from Streptomyces).