Given below are two statements: Statement I: RNA secondary structure is composed primarily of double-stranded RNA regions formed by folding of the…
Given below are two statements:Statement I: RNA secondary structure is composed primarily of double-stranded RNA regions formed by folding of the single-stranded molecule back on itself.Statement II: Like protein secondary structure, RNA secondary structure can be conveniently viewed as an intermediate step in the formation of a three-dimensional structure.In the light of the above statements, choose the most appropriate answer from the options given below:
Select an option to attempt
Correct Answer: Option A
Explanation
RNA secondary structure: analogy to protein secondary structure:RNA is a single-stranded molecule that folds upon itself through intramolecular base pairing (A-U, G-C, and non-canonical G-U wobble pairs) to form secondary structures:• RNA secondary structures: stem-loops/hairpins, internal loops, bulges, multi-branch loops, pseudoknots.• These are double-stranded regions formed by base-pairing within the single-stranded RNA molecule.Analogy to protein structure:• Primary structure: sequence (nucleotides for RNA; amino acids for proteins)• Secondary structure: local regular structures (stem-loops for RNA;-helices and-sheets for proteins)• Tertiary structure: overall 3D fold (for rRNA, tRNA, ribozymes; protein domain folds)RNA secondary structure is the intermediate structural organisation — double-stranded regions within a single-stranded molecule — analogous to local folding in proteins.Answer: RNA secondary structure (stems and loops from intramolecular base pairing) is analogous to protein secondary structure.