Topic

Bioinformatics PYQs

23 previous year questions across 16 subtopics · answers and explanations included

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One question at a time, instant feedback, score at the end.

Showing 23 questions · page 1 of 2

1

The sequence CGAATTTGG is matched globally with four sequences in a database. The sequence that will give the highest similarity score taking match =1, mismatch = 0 and gap penalty = minus 1 is

HardView answer

2

Which one of the following CANNOT be used for progressive global multiple sequence alignment?

MediumMultiple Sequence Alignment ToolsView answer

3

BLOSUM matrix is used for

MediumView answer

4

Computational Prediction of protein folding assumes that

HardView answer

5

Genes related through vertical descent from a common ancestral gene are called

EasyView answer

6

Accuracy of Protein Structure Prediction can be assessed using tools like

HardView answer

7

Given below are two statements one is labelled as Assertion A and the other is labelled as Reason R: Assertion A: The dot matrix method of sequence alignment is a very basic method that should be used first, before other more complex methods. Reason R: The…

MediumSequence Alignment - Dot Matrix MethodView answer

8

Given below are two statements: Statement I: An alignment is generated by starting at the ends of the two sequences and attempting to match all possible pairs of characters between the sequences and by following a scoring scheme for matches, mismatches, and…

MediumPairwise Sequence Alignment & Scoring MatricesView answer

9

Given below are two statements: Statement I: RNA secondary structure is composed primarily of double-stranded RNA regions formed by folding of the single-stranded molecule back on itself. Statement II: Like protein secondary structure, RNA secondary…

MediumRNA Secondary Structure PredictionView answer

10

Which of the following represents a quantitative measure of the structural similarity between two proteins?

MediumView answer

11

Which one of the following DOES NOT represent known interactions of RNA secondary structural elements?

MediumRNA Structural InteractionsView answer

12

Which one of the following can be considered as a Data Matrix?

MediumData Structures in R/ProgrammingView answer

13

Which one of the following can be considered as an Atomic Vector?

MediumData Structures in R - Atomic VectorsView answer

14

Which one of the following lines of unix commands can tell you the number of lines in a file?

MediumUnix/Linux Commands for BioinformaticsView answer

15

Which one of the following is NOT a Data Type?

MediumData Types in ProgrammingView answer

16

Which one of the following is comparatively the best E-value to a pairwise sequence match?

MediumBLAST & E-value InterpretationView answer

17

Phylogenetic tree provides information about

EasyView answer

18

Your friend runs a BLASTp on his unknown sequence and finds a match with E-value of 3 with a target. What does this mean?

MediumBLAST Search & Statistical SignificanceView answer

19

During analysis of Next-Gen Sequencing data, what is the advantage of BAM files over SAM files?

MediumNGS Data Formats - BAM vs SAMView answer

20

The measure of similarity between two structurally aligned macromolecules is:

MediumStructural Bioinformatics - RMSDView answer