Which one of the following CANNOT be used for progressive global multiple sequence alignment?
Which one of the following CANNOT be used for progressive global multiple sequence alignment?
Select an option to attempt
Correct Answer: Option B
Explanation
LALIGN and multiple sequence alignment:Bioinformatics tools for sequence alignment:• LALIGN: Finds multiple LOCAL alignments between TWO sequences (pairwise). Based on Smith-Waterman algorithm. Identifies non-overlapping similar regions within the same pair. NOT for multiple sequence alignment.• ClustalW: Progressive global multiple sequence alignment of protein or DNA sequences.• PILEUP (GCG): Progressive multiple sequence alignment tool.• T-COFFEE: Multiple sequence alignment that uses pairwise alignments to guide progressive alignment; generally more accurate than ClustalW.The tool NOT used for progressive global multiple sequence alignment is LALIGN.Answer: LALIGN (it performs pairwise local alignment, not progressive multiple sequence alignment).