Ligands 'A' and 'B' bind to protein 'P' with dissociation constants of 1 nM and 100 nM, respectively. Which of the following is true?
Ligands 'A' and 'B' bind to protein 'P' with dissociation constants of 1 nM and 100 nM, respectively. Which of the following is true?
Select an option to attempt
Correct Answer: Option C
Explanation
Dissociation constant. A lowerindicates tighter binding (higher affinity). Ligand A:(very tight binding). Ligand B:(100× weaker binding). Affinity is inversely proportional to:. Therefore A binds protein P with 100× greater affinity than B. This is the basis for therapeutic drug selection — compounds with lowervalues are typically more potent.