RTS,S vaccine for malaria consists of the central repeat (R) region derived from Plasmodium falciparum circumsporozoite protein (CSP) that is…
RTS,S vaccine for malaria consists of the central repeat (R) region derived from Plasmodium falciparum circumsporozoite protein (CSP) that is genetically fused to the T-cell epitope (T) and surface antigen (S) regions derived from:
Select an option to attempt
Correct Answer: Option B
Explanation
RTS,S malaria vaccine composition:RTS,S (Mosquirix, developed by GSK/PATH) is the first approved malaria vaccine:• R: Central repeat region of P. falciparum circumsporozoite protein (CSP) — NANP repeat units• T: T-cell epitope region of CSP (C-terminal)• S: HBsAg (Hepatitis B surface antigen)The entire R and T portions are fused to HBsAg (S = surface antigen), expressed in Saccharomyces cerevisiae (baker's yeast).The fusion protein self-assembles into virus-like particles (VLPs) that display the CSP epitopes in an immunogenic form.Adjuvant: AS01B (liposomes + MPL + QS21) dramatically enhances immune response.Efficacy: ~30–50% protection against clinical malaria in young children.Answer: RTS,S contains CSP repeat (R), T-cell epitope (T) fused to HBsAg (S), expressed in yeast.