The motifs commonly found in the core promoter of eukaryotic protein coding genes are:
The motifs commonly found in the core promoter of eukaryotic protein coding genes are:
Select an option to attempt
Correct Answer: Option B
Explanation
Core promoter elements in eukaryotic protein-coding genes:• TATA box: Located ~25–30 bp upstream of the transcription start site (TSS); recognised by TATA-Binding Protein (TBP), a subunit of TFIID.• Motif Ten Element (MTE): Located ~18–27 bp downstream of the TSS; functions similarly to the TATA box in directing Pol II.Distractors explained:• Pribnow box (TATAAT): Found in prokaryotic promoters at −10; NOT in eukaryotes.• Kozak consensus sequence: Surrounds the AUG start codon in eukaryotic mRNAs; it is a translation initiation signal, not a transcription promoter element.• BRE (TFIIB Recognition Element): Located upstream of the TATA box; recognised by TFIIB, not TFIID.• TRE (TPA Response Element): A transcriptional enhancer element responsive to phorbol esters, not a core promoter motif.